Bioactivity:

HMG499 is a potent and selective HMG-CoA reductase inhibitor (IC50: 0.41 _M). HMG499 can prevent the statins-induced accumulation of HMGCR, reduce serum cholesterol levels, and decrease atherosclerosis.

CAS nr:

T11572

Purity:

98%

Molecular Weight:

498,78

SMILES:

O[C@H](C1(C)C)CC[C@@]2(C)C1=C[C@H](O)C3C2CC[C@@]4(C)C3CC[C@@H]4[C@@H](CCCC(CC=C)(O)CC=C)C

Formula:

C33H54O3

Pathway:

Metabolism

Target:

HMG-CoA Reductase