Bioactivity:

Oxychlororaphine is a phenazine microbial metabolite that has been found in a variety of bacteria and has anticancer, antibacterial, and antifungal activities.1,2 It is cytotoxic to A549, HeLa, and SW480 cancer cells (IC50s = 32-40 _M).1 Oxychlororaphine halts the cell cycle at the G1 phase and induces apoptosis in A549 cells. It is active against Streptomyces bacteria and T. mentagrophytes, E. floccosum, C. albicans, M. audouini, and B. dermatitidis fungi when used at concentrations ranging from 12.5 to 50 ppm.2References1. Ali, H.M., El-Shikh, M.S., Salem, M.Z.M., et al. Isolation of bioactive phenazine-1-carboxamide from the soil bacterium Pantoea agglomerans and study of its anticancer potency on different cancer cell lines. J. AOAC Int. 99(5), 1233-1239 (2016).2. Sierra, G., and Veringa, H.A. Effect of oxy-chlororaphin on the growth in vitro of Streptomyces species and some pathogenic fungi. Nature 182(4630), 265 (1958). Oxychlororaphine is a phenazine microbial metabolite that has been found in a variety of bacteria and has anticancer, antibacterial, and antifungal activities.1,2 It is cytotoxic to A549, HeLa, and SW480 cancer cells (IC50s = 32-40 _M).1 Oxychlororaphine halts the cell cycle at the G1 phase and induces apoptosis in A549 cells. It is active against Streptomyces bacteria and T. mentagrophytes, E. floccosum, C. albicans, M. audouini, and B. dermatitidis fungi when used at concentrations ranging from 12.5 to 50 ppm.2 References1. Ali, H.M., El-Shikh, M.S., Salem, M.Z.M., et al. Isolation of bioactive phenazine-1-carboxamide from the soil bacterium Pantoea agglomerans and study of its anticancer potency on different cancer cell lines. J. AOAC Int. 99(5), 1233-1239 (2016).2. Sierra, G., and Veringa, H.A. Effect of oxy-chlororaphin on the growth in vitro of Streptomyces species and some pathogenic fungi. Nature 182(4630), 265 (1958).

CAS nr:

550-89-0

Purity:

98%

Molecular Weight:

223,235

SMILES:

NC(=O)c1cccc2nc3ccccc3nc12

Formula:

C13H9N3O

Pathway:

Microbiology/Virology

Target:

Antibacterial