Bioactivity:

NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.

CAS nr:

6964-62-1

Purity:

98%

Molecular Weight:

340,418

SMILES:

Cc1ccc2ccc(C(Nc3ccccc3)c3ccccc3)c(O)c2n1

Formula:

Pathway:

Apoptosis

Target:

Mdm2