Bioactivity:

Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.

CAS nr:

1369761-01-2

Purity:

98%

Molecular Weight:

482

SMILES:

Cl.CCS(=O)(=O)N1CCN(CC1)C1=CC=C(NC2=NC(NC3CC3)=C(C=N2)C(N)=O)C=C1

Formula:

C20H28ClN7O3S

Pathway:

Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,Angiogenesis,Tyrosine Kinase/Adaptors,Stem Cells,Stem Cells,Tyrosine Kinase/Adaptors,MAPK,Tyrosine Kinase/Adaptors

Target:

JAK,JAK,JAK,Syk,Syk,JAK,Hippo pathway,Tyrosine Kinases,MLK,c-Fms