Bioactivity:

GLPG0634(filgotinib) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.

CAS nr:

1206161-97-8

Purity:

98%

Molecular Weight:

425,5

SMILES:

O=C(Nc1nn2c(cccc2c2ccc(CN3CCS(=O)(=O)CC3)cc2)n1)C1CC1

Formula:

C21H23N5O3S

Pathway:

Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,Stem Cells,Tyrosine Kinase/Adaptors

Target:

JAK,JAK,JAK,JAK,Tyrosine Kinases