Bioactivity:

Ruxolitinib phosphate(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.

CAS nr:

1092939-17-7

Purity:

98%

Molecular Weight:

404,36

SMILES:

OP(O)(O)=O.N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12

Formula:

C17H21N6O4P

Pathway:

JAK/STAT signaling,Chromatin/Epigenetic,Stem Cells,Angiogenesis,Autophagy,Autophagy

Target:

JAK,JAK,JAK,JAK,Autophagy,Mitophagy