Bioactivity:

Pyridone 6(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.

CAS nr:

457081-03-7

Purity:

98%

Molecular Weight:

309,34

SMILES:

CC(C)(C)c1nc2c([nH]1)c1ccc(F)cc1c1c2cc[nH]c1=O

Formula:

C18H16FN3O

Pathway:

Stem Cells,Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,Tyrosine Kinase/Adaptors

Target:

JAK,JAK,JAK,JAK,Tyrosine Kinases