Bioactivity:

MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.

CAS nr:

1038915-60-4

Purity:

98%

Molecular Weight:

320,39

SMILES:

c1(cccc2c1nn(c2)c1ccc(cc1)[C@H]1CNCCC1)C(=O)N

Formula:

C19H20N4O

Pathway:

DNA Damage/DNA Repair,Chromatin/Epigenetic,Others,Apoptosis

Target:

PARP,PARP,Others,Apoptosis