Bioactivity:

JNJ-54166060 is a potent P2X7 antagonist. rP2X7 IC50=4 nM; rP2X7 IC50=115nM; HLM/RLM = 0.35/0.64, ED50 = 2.3 mg/kg in rats. JNJ-54166060 possesses a unique CYP profile and was found to be a regioselective inhibitor of midazolam CYP3A metabolism.

CAS nr:

1627900-42-8

Purity:

98%

Molecular Weight:

438,81

SMILES:

ClC1=C(C(N2CCC(N(C3=CC=C(F)C=N3)C=N4)=C4[C@H]2C)=O)C=CC=C1C(F)(F)F

Formula:

C20H15ClF4N4O

Pathway:

Target: