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Bioactivity:
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
CAS nr:
1874232-80-0
Purity:
98%
Molecular Weight:
473,5
SMILES:
O=C(C1=NC=C(OCC#C)N=C1)NC2=CC(F)=C(F)C([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@@]34[H])=C2
Formula:
C22H21F2N5O3S
Pathway:
Neuroscience
Target:
BACE