Bioactivity:

JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POL_. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 _M; Kd=0.42 _M), which targets REV1 that interacts with the REV7 subunit of POL_. JH

CAS nr:

1361227-90-8

Purity:

98%

Molecular Weight:

468,72

SMILES:

O=C1C(C(CC(C)C)=O)=C(NC2=CC=C(Cl)C=C2Cl)NC3=C1C([N+]([O-])=O)=CC=C3Cl

Formula:

C20H16Cl3N3O4

Pathway:

DNA Damage/DNA Repair,Cell Cycle/Checkpoint

Target:

DNA/RNA Synthesis,DNA/RNA Synthesis