Bioactivity:

ABT-199 is a selective inhibitor of Bcl-2 (Ki < 0.010 nM), binding over 3 orders of magnitude less avidly to Bcl-xL, and Bcl-W (Kis = 48 and 245 nM, respectively).

CAS nr:

1257044-40-8

Purity:

98%

Molecular Weight:

868,44

SMILES:

CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1

Formula:

C45H50ClN7O7S

Pathway:

Apoptosis,Autophagy

Target:

BCL,Autophagy