Bioactivity:

PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 _M in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].

CAS nr:

T17728

Purity:

98%

Molecular Weight:

748,74

SMILES:

O=C(C=C(C1=CC=CC=C1)O2)C3=C2C(OCC4=CN(CCCCCCCC(NC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)N=N4)=C(O)C=C3O

Formula:

C39H36N6O10

Pathway:

Others

Target:

Others