Bioactivity:

TC-S 7009 is more selective for HIF-2_ than HIF-1_ (Kd _ 5 _M). TC-S 7009 is an effective and selective inhibitor of HIF-2_ (Kd: 81 nM). TC-S 7009 disrupts HIF-2_ heterodimerization, decreases DNA-binding activity, and reduces HIF-2_ target gene expressio

CAS nr:

1422955-31-4

Purity:

98%

Molecular Weight:

308,65

SMILES:

ClC1=CC(NC2=C([N+]([O-])=O)C3=NON=C3C=C2)=CC(F)=C1

Formula:

C12H6ClFN4O3

Pathway:

Angiogenesis,Chromatin/Epigenetic

Target:

HIF,HIF