Bioactivity:

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

CAS nr:

939791-41-0

Purity:

98%

Molecular Weight:

543,95

SMILES:

Formula:

C21H20F3N7O3S HCl

Pathway:

Tyrosine Kinase/Adaptors,Cytoskeletal Signaling,Angiogenesis,Tyrosine Kinase/Adaptors,Cell Cycle/Checkpoint

Target:

FAK,FAK,FAK,PYK2,CDK