Bioactivity:

Copanlisib dihydrochloride is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3K_, PI3K_, PI3K_ and PI3K_). Copanlisib dihydrochloride has superior antitumor activity and it also has more than 2,000-fold selec

CAS nr:

1402152-13-9

Purity:

98%

Molecular Weight:

553,44

SMILES:

O=C(C1=CN=C(N)N=C1)NC2=NC3=C(C=CC(OCCCN4CCOCC4)=C3OC)C5=NCCN25.[H]Cl.[H]Cl

Formula:

C23H30Cl2N8O4

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,Apoptosis

Target:

mTOR,PI3K,Apoptosis