Bioactivity:

Tandutinib (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 _M), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR, and KDR.

CAS nr:

387867-13-2

Purity:

98%

Molecular Weight:

562,7

SMILES:

N1(CCN(CC1)c1ncnc2c1cc(c(c2)OCCCN1CCCCC1)OC)C(=O)Nc1ccc(cc1)OC(C)C

Formula:

C31H42N6O4

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Apoptosis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors

Target:

PDGFR,PDGFR,FLT,FLT,CSF-1R,Apoptosis,Src,Src,c-Kit