Bioactivity:

CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.

CAS nr:

21919-05-1

Purity:

98%

Molecular Weight:

252,18

SMILES:

NC(=O)c1c(cc(c(c1)N1CC1)[N+](=O)[O-])[N+](=O)[O-]

Formula:

C9H8N4O5

Pathway:

DNA Damage/DNA Repair,DNA Damage/DNA Repair

Target:

DNA Alkylation,DNA Alkylator/Crosslinker