Bioactivity:

2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 _M. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 _M[1][2][3]. [1]. Laura E Korhonen, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15. [2]. L E Korhonen, et al. New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. Br J Pharmacol. 2007 Apr;150(7):932-42. [3]. Cun Zhang, et al. Studies on chemical constituents from roots of Peucedanum praeruptorum II. Zhongguo Zhong Yao Za Zhi. 2006 Aug;31(16):1333-5.

CAS nr:

877-43-0

Purity:

98%

Molecular Weight:

157,216

SMILES:

Cc1ccc2nc(C)ccc2c1

Formula:

C11H11N

Pathway:

Metabolism

Target:

P450