Bioactivity:

JNJ-_10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-_ kinase (IC50=4.2 nM) and PDGFR-_ kinase (IC50=45 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antipro

CAS nr:

627518-40-5

Purity:

98%

Molecular Weight:

325,34

SMILES:

COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC

Formula:

C18H16FN3O2

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors

Target:

PDGFR,PDGFR