Bioactivity:

Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dis

CAS nr:

594839-88-0

Purity:

98%

Molecular Weight:

308,12

SMILES:

OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1

Formula:

C14H7Cl2NO3

Pathway:

Others

Target:

Others