Bioactivity:

YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13.

CAS nr:

1957203-01-8

Purity:

98%

Molecular Weight:

515,61

SMILES:

CC(C)(c1c(C2)c(NC(c(cc3)ccc3NC(C=C)=O)=O)n[nH]1)N2C(N[C@H](CN(C)C)c1ccccc1)=O

Formula:

C28H33N7O3

Pathway:

Cell Cycle/Checkpoint

Target:

CDK