Bioactivity:

GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 _M, 0.43 _M, 20.3 _M and 0.23 _M for full length USP7, USP7 catalytic domain, full length USP43 and Ub-MDM2, respectively.

CAS nr:

2009273-67-8

Purity:

98%

Molecular Weight:

330,39

SMILES:

CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc2[nH]ncc2c1

Formula:

C20H18N4O

Pathway:

Ubiquitination,Cell Cycle/Checkpoint,DNA Damage/DNA Repair

Target:

DUB,DUB,DUB