Bioactivity:

TCS 21311 is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKC_, PKC_, and GSK3_ (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK2, and TYK2.

CAS nr:

1260181-14-3

Purity:

98%

Molecular Weight:

526,51

SMILES:

CC(C)(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)C(F)(F)F)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54)O

Formula:

C27H25F3N4O4

Pathway:

JAK/STAT signaling,Chromatin/Epigenetic,Stem Cells,Angiogenesis,Stem Cells,PI3K/Akt/mTOR signaling,Chromatin/Epigenetic,Cytoskeletal Signaling

Target:

JAK,JAK,JAK,JAK,GSK-3,GSK-3,PKC,PKC