Bioactivity:

Volasertib (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).

CAS nr:

755038-65-4

Purity:

98%

Molecular Weight:

618,81

SMILES:

CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O

Formula:

C34H50N8O3

Pathway:

Cell Cycle/Checkpoint,Apoptosis

Target:

PLK,Apoptosis