Bioactivity:

AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38_, Tyk2, JNK2, Met and Tie2. Phase 1.

CAS nr:

945595-80-2

Purity:

98%

Molecular Weight:

503,58

SMILES:

CC1=CSC(=C1)C1=NN=C(NC2=CC=C(OC3=C(C=CC=N3)C3=NC(N)=NC=C3)C=C2)C2=C1C=CC=C2

Formula:

C28H21N7OS

Pathway:

Cell Cycle/Checkpoint,Chromatin/Epigenetic,MAPK,Tyrosine Kinase/Adaptors

Target:

Aurora Kinase,Aurora Kinase,p38 MAPK,Tyrosine Kinases