Bioactivity:

Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM toward A549 cells.

CAS nr:

1414455-03-0

Purity:

98%

Molecular Weight:

474,6

SMILES:

C\C1=C/CC(C)(C)\C=C\C[C@@]2(C)Oc3c(C=O)c(O)c(C=O)c(O)c3[C@H]([C@@H]2CC1)c1ccccc1

Formula:

C30H34O5

Pathway:

DNA Damage/DNA Repair

Target:

Topoisomerase