Bioactivity:

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 _M, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

CAS nr:

475489-15-7

Purity:

98%

Molecular Weight:

453,59

SMILES:

NC1=NC=NC2=C1C(=CN2C1CC(CN2CCCC2)C1)C1=CC(OCC2=CC=CC=C2)=CC=C1

Formula:

C28H31N5O

Pathway:

Tyrosine Kinase/Adaptors

Target:

IGF-1R