Bioactivity:

JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210 .1JKE-1674 reduces viability of LOX-IMVI cancer cells (EC50= 0.03 _M) and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 . 1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)

CAS nr:

2421119-60-8

Purity:

98%

Molecular Weight:

451,3

SMILES:

O=C(C(C[N+]([O-])=O)=NO)N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1

Formula:

C20H20Cl2N4O4

Pathway:

oxidation-reduction

Target:

GPX