Bioactivity:

PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 _M) and Bcl-2 (IC50: 4.94 _M; DC50: 3.0 _M).

CAS nr:

2378801-85-3

Purity:

98%

Molecular Weight:

941,84

SMILES:

O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O

Formula:

C45H45BrN6O10S

Pathway:

Apoptosis

Target:

BCL