Bioactivity:

AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 _M and 0.035 _M, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 _M, 0.245 _M, and >1_M, respectively. AES-350 tri

CAS nr:

847249-57-4

Purity:

98%

Molecular Weight:

312,36

SMILES:

CC(C)(C)C1=CC=C(C(NC2=CC=C(C(NO)=O)C=C2)=O)C=C1

Formula:

C18H20N2O3

Pathway:

DNA Damage/DNA Repair,Chromatin/Epigenetic,Apoptosis

Target:

HDAC,HDAC,Apoptosis