Bioactivity:

Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.

CAS nr:

1640292-55-2

Purity:

98%

Molecular Weight:

453,51

SMILES:

OC(=O)\C=C/C(O)=O.CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)C1=C2C=CNC2=NC=N1

Formula:

C15H23N5O2S�C4H4O4

Pathway:

JAK/STAT signaling,Chromatin/Epigenetic,Stem Cells,Angiogenesis,Tyrosine Kinase/Adaptors

Target:

JAK,JAK,JAK,JAK,Tyrosine Kinases