Bioactivity:

GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effect

CAS nr:

1202580-59-3

Purity:

98%

Molecular Weight:

439,55

SMILES:

O=C(CCCCCCCN1N=NC(C2=CN=CC=C2)=C1)NC3=CC=CC=C3C4=CC=CC=C4

Formula:

C27H29N5O

Pathway:

Autophagy

Target:

Autophagy