Bioactivity:

A 83-01 sodium salt is a potent inhibitor of ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50s: 12, 45 and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7).

CAS nr:

T10442

Purity:

98%

Molecular Weight:

444,51

SMILES:

S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5.[Na+]

Formula:

C25H19N5NaS

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis

Target:

ALK,ALK