Bioactivity:

Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin causes cell apoptosis.

CAS nr:

1173671-63-0

Purity:

98%

Molecular Weight:

358,4

SMILES:

O=C(N/N=C/C1=CC=C2N=CC=NC2=C1)[C@H](N)CC3=CNC4=C3C=CC=C4

Formula:

C20H18N6O

Pathway:

Cell Cycle/Checkpoint

Target:

Rho