Bioactivity:

BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 _M. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 _M. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of

CAS nr:

34576-94-8

Purity:

98%

Molecular Weight:

247,1

SMILES:

OC(=O)c1sc2cc(Cl)ccc2c1Cl

Formula:

C9H4Cl2O2S

Pathway:

Apoptosis

Target:

BCL