Bioactivity:

(E)-Necrosulfonamide is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from inte

CAS nr:

1360614-48-7

Purity:

98%

Molecular Weight:

461,47

SMILES:

C(=O)(/C=C/c1ccc(s1)[N+](=O)[O-])Nc1ccc(cc1)S(=O)(=O)Nc1c(nccn1)OC

Formula:

C18H15N5O6S2

Pathway:

MAPK

Target:

MLK