Bioactivity:

R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3_/_, while inactive to other kinases. Phase 1.

CAS nr:

741713-40-6

Purity:

98%

Molecular Weight:

441,45

SMILES:

COC1=CC=C(F)C(F)=C1C(=O)C1=C(N)N=C(NC2CCN(CC2)S(C)(=O)=O)N=C1

Formula:

C18H21F2N5O4S

Pathway:

Tyrosine Kinase/Adaptors,Stem Cells,PI3K/Akt/mTOR signaling,Apoptosis,Cell Cycle/Checkpoint

Target:

PKA,GSK-3,GSK-3,Apoptosis,CDK