Bioactivity:

Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50s: 0.035, 1.3, 4.6, 7 and 11.3 nM).

CAS nr:

849217-68-1

Purity:

98%

Molecular Weight:

501,5

SMILES:

COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC

Formula:

C28H24FN3O5

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Apoptosis,Tyrosine Kinase/Adaptors,Apoptosis,Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors

Target:

VEGFR,VEGFR,c-RET,c-RET,TAM Receptor,Apoptosis,FLT,FLT,c-Met/HGFR,c-Kit