Bioactivity:

PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.

CAS nr:

1873373-33-1

Purity:

98%

Molecular Weight:

474,38

SMILES:

NC1=C(O[C@@H]2C(F)(F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C2)C=C(C(NC)=O)C=N1

Formula:

C20H19F5N4O4

Pathway:

Tyrosine Kinase/Adaptors

Target:

Trk receptor