Bioactivity:

AZD3759 (hydrochloride) is an effective, orally active and central nervous system-penetrant�EGFR�inhibitor. At Km�ATP concentrations, the�IC50s are 0.2/0.3/0.2 nM for EGFR (L858R)/EGFR (wt)/EGFR (exon 19Del).

CAS nr:

1626387-81-2

Purity:

98%

Molecular Weight:

496,36

SMILES:

C[C@@H]1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C.Cl

Formula:

C22H24Cl2FN5O3

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

EGFR,EGFR,EGFR