Bioactivity:

CHMFL-PI3KD-317 is a highly potent, selective, and orally active PI3K_ inhibitor (IC50: 6 nM) with the antiproliferative effects on cancer cells. It inhibits PI3K_-mediated Akt T308 phosphorylation in Raji cells (EC50: 4.3 nM).

CAS nr:

2244992-76-3

Purity:

98%

Molecular Weight:

494,03

SMILES:

ClC1=C(NS(=O)(C2=CC(C)=CC=C2)=O)C=C(C3=C(C)N=C(NC([C@H](C(C)C)N)=O)S3)C=N1

Formula:

C21H24ClN5O3S2

Pathway:

PI3K/Akt/mTOR signaling

Target:

PI3K