Bioactivity:

EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.

CAS nr:

1598383-40-4

Purity:

98%

Molecular Weight:

605,81

SMILES:

CCN([C@H]1CC[C@@H](CC1)N(C)CCOC)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#CCN1CCOCC1

Formula:

C35H51N5O4

Pathway:

Chromatin/Epigenetic

Target:

Histone Methyltransferase