Bioactivity:

GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, respectively).

CAS nr:

1936421-41-8

Purity:

98%

Molecular Weight:

510,58

SMILES:

CC(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)=O

Formula:

C27H32F2N6O2

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain