Bioactivity:

JAK3i is a selective covalent inhibitor of JAK3 kinase. JAK3i reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cell proliferation.

CAS nr:

1918238-72-8

Purity:

98%

Molecular Weight:

354,34

SMILES:

O=C(C1=CNC2=NC=NC(C3=CC(NC(C=C)=O)=CC=C3F)=C21)OCC

Formula:

C18H15FN4O3

Pathway:

Target: