Bioactivity:

AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397 (example 39; IC50 < 0.5 ﾵ_). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1.

CAS nr:

2247953-39-3

Purity:

98%

Molecular Weight:

550,89

SMILES:

CC(C1=C2N(N=C1)C(N[C@H]3CC(C4=CC=CC=C4N5)=C5CC3)=NC(C6=CN=CC(F)=C6)=N2)C.Cl.Cl.Cl

Formula:

C25H27Cl3FN7

Pathway:

Others

Target:

Others