Bioactivity:

Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKC_ of 3-6 _M, PKC_,_,_ of 30-42 _M, PKC_,_,_ of 80-100 _M). Rottlerin causes apoptosis via caspase 3 activation.

CAS nr:

1982/8/6

Purity:

98%

Molecular Weight:

516,54

SMILES:

O=C(C1=C2C(C=CC(C)(C)O2)=C(O)C(CC3=C(O)C(C)=C(O)C(C(C)=O)=C3O)=C1O)/C=C/C4=CC=CC=C4

Formula:

C30H28O8

Pathway:

Neuroscience,Tyrosine Kinase/Adaptors,Proteases/Proteasome,Microbiology/Virology,Others,Autophagy,Apoptosis,Cytoskeletal Signaling,Chromatin/Epigenetic

Target:

CaMK,PKA,HIV Protease,HIV Protease,Others,Autophagy,Apoptosis,PKC,PKC