Bioactivity:

WP1066 is a inhibitor of JAK2 (IC50: 2.30 _M) and STAT3 (IC50: 2.43 _M) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Centra

CAS nr:

857064-38-1

Purity:

98%

Molecular Weight:

356,22

SMILES:

C[C@@H](c1ccccc1)NC(=O)/C(=C/c1nc(ccc1)Br)/C#N

Formula:

C17H14BrN3O

Pathway:

Chromatin/Epigenetic,Stem Cells,JAK/STAT signaling,Stem Cells,Angiogenesis,JAK/STAT signaling,Apoptosis

Target:

JAK,STAT,STAT,JAK,JAK,JAK,Apoptosis