Bioactivity:

OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3K_, PI3K_, PI3K_ or DNA-PK. Phase 1.

CAS nr:

936890-98-1

Purity:

98%

Molecular Weight:

406,44

SMILES:

COC1=CC=CC2=C1NC(=C2)C1=C2N(N=CN=C2N)C(=N1)[C@H]1CC[C@@H](CC1)C(O)=O

Formula:

C21H22N6O3

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,Autophagy,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair

Target:

mTOR,PI3K,Autophagy,DNA-PK,DNA-PK