Bioactivity:

GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of_>2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells).

CAS nr:

2158266-58-9

Purity:

98%

Molecular Weight:

510,59

SMILES:

O=C(NC)C1=NC=C(C2=CC3=C(C=N2)C(C4=NN(C5CCOCC5)C6=C4CN(C(C)=O)CC6)=CC=C3)C=C1

Formula:

C29H30N6O3

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain